Outside of the 12 games on Sunday, we have a pivotal AFC West matchup next Monday night between the Broncos and Chargers in Los Angeles. The Chargers are six-point favorites after coming off a tough win over the Browns on the road, while the Broncos are trying to snap their two-game losing skid and pick up a win in the division. We also have our first set of byes this season with the Lions, Titans, Raiders, and Texans getting a much-needed week off.

Please remember that the odds and lines will move throughout the week as we get updates on various injuries across the league. There could be some opportunity for closing line value (CLV) in a few games leading up to kickoff. Below, we take a look at the latest odds for Week 6 from Caesars Sportsbook and provide a few best bets that need to be on your radar.

NFL odds Week 6

Odds courtesy of Caesar’s and updated on Sunday morning at 11 AM ET

NFL moneylines Week 6

NFL over/unders Week 6

NFL best bets for Week 6

Bengals (-170) at Saints

The Bengals are coming off a tough road loss to the Ravens in Week 5, while the Saints snuck away with a seven-point win at home over Seattle. Cincinnati should be able to ride its defense (17.8 points, 99.6 rushing yards per game) to a win over a Saints squad that is banged up on offense (Jameis Winston, Michael Thomas, Jarvis Landry, Chris Olave). This should be a big Joe Mixon game, too, as the Saints’ defense is allowing 130 rushing yards per game. Cincinnati is 4-2 straight up in their past six games against New Orleans and 5-1 ATS over that span.

Falcons (+4) vs. 49ers

It’s only right for us to take the Falcons to cover the spread at home against the 49ers. Even though they lack talent at a bunch of skill positions, Atlanta head coach Arthur Smith has his team playing competitive football. In their three losses this season, the Falcons have only lost by 3.6 points per game. They’ve played the Buccaneers, Rams, and Browns all tough this season. The Niners are riding a two-game winning streak, but I don’t believe they are almost a touchdown better than Atlanta. San Francisco beat up the Panthers and took down the Rams at SoFi Stadium in consecutive weeks. However, they also lost to Denver in a slop fest of a game. With Drake London set to play and the Falcons’ ability to run the ball, they will keep it close at home.

Cardinals vs. Seahawks (+115)

Every week in the NFL, there’s always guaranteed to be a few upsets that catch football fans and bettors off guard. In Week 6, we will take Seattle to pull the upset at home over Kyler Murray and Arizona. Seattle has played good complementary football through the first five games of the season. Geno Smith has been locked in under center, completing 75 percent of his passes for 1,305 yards, nine touchdown passes, and two interceptions. The Seahawks will be without Rashaad Penny (fractured fibula), but they have a good rookie running back in Kenneth Walker III. Both teams’ defenses will give up a ton of points, but you gotta love the consistency Smith and the offense are playing with. Take the Seahawks to pull the upset in the waning moments of the fourth quarter.