Mack made first-team All-Pro at defensive end and linebacker, becoming the first player to earn the honor at multiple positions in the same season. He played 439 snaps at outside linebacker and 467 at defensive end.
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The only unanimous picks this season were Vikings running back Adrian Peterson and Texans defensive end J.J. Watt. The Panthers led all teams with six first-team selections.
Seahawks returner and receiver Tyler Lockett was the only rookie to make the team.
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The full first-team All-Pro roster:
Offense
QB: Cam Newton, Panthers
RB: Adrian Peterson, Vikings; Doug Martin, Buccaneers
FB: Mike Tolbert, Panthers
WR: Antonio Brown, Steelers; Julio Jones, Falcons
TE: Rob Gronkowski, Patriots
T: Andrew Whitworth, Bengals; Joe Thomas, Browns
G: David DeCastro, Steelers; Marshal Yanda, Ravens
C: Ryan Kalil, Panthers
Defense
DE: J.J. Watt, Texans; Khalil Mack, Raiders
DT: Aaron Donald, Rams; Geno Atkins, Bengals
LB: Thomas Davis, Panthers; Luke Kuechly, Panthers; Khalil Mack, Raiders; Von Miller, Broncos; NaVorro Bowman, 49ers
CB: Josh Norman, Panthers; Patrick Peterson, Cardinals
S: Tyrann Mathieu, Cardinals; Eric Berry, Chiefs
Special teams
K: Stephen Gostkowski, Patriots
P: Johnny Hekker, Rams
KR: Tyler Lockett, Seahawks